Liver Damage Due To Sleep Apnea
Written by clive on 11:41 PMLiver damage due to sleep apnea
Patients with OSA were studied and examined in the first study, and researchers headed by the Laolunshisaier Diboshi law faculties in the liver St. - Antoine Hospital in Paris, France in patients with liver function tests being evaluated for OSA , to determine whether sleep apnea by itself is a risk factor for liver disease and if so, the mechanism involved with liver damage due to sleep apnea.
The findings of the study published in the June 2005 issue of the liver, the official magazine of the American Chamber of Commerce, to study liver disease (aasld), published by John Wiley & Sons Publishing Company in the liver via the Internet on publishing interscience HTTP: / / www.interscience.wiley.com / journal / liver disease.
The study included 163 patients were referred to the unit's sleep - Antoine Hospital, from September 2000 to May 2001 evaluation for OSA. Concentration in the blood of liver enzymes in the morning after sleeping in the clinics, patients with elevated levels of liver biopsy for a while, in the morning. Patients were divided into groups according to degree of severity of OSA: severe (44 patients), moderate (84 cases), or non-existent (35 patients). This last group, no OSA, was used as a control group. Elevated liver enzymes, found 32 cases, 29 were in the severe or moderate group. Liver biopsy performed in 18 of these patients: 9 severe OSA, 6 moderate OSA and three non-OSA. Severe OSA have a significantly higher percentage of fat (fatty liver disease), lobular necrosis and fibrosis (two signs of liver damage) than patients in the other two groups, regardless of body mass index (BMI), which itself was a known as risk factors, fatty liver disease liver damage due to sleep apnea. They also have a significantly higher level of insulin and insulin more resistant than the other patients.
Although the author pointed out that the study results should be considered very carefully because of the limited number of patients for liver biopsy, and their conclusion is that severe OSA, independent of overweight is a risk factor for liver disease with liver damage due to sleep apnea. In addition, they postulate that OSA may contribute to insulin resistance and fatty liver disease, since insulin response capabilities, enhance, the OSA. They suggested striking relationship between the severity of sleep apnea and liver damage indicates that OSA may play a role, how the development of fatty liver disease.
"In conclusion," the authors state, "OSA is a risk factor for abnormal liver enzymes independent of the body mass index, and should be investigated for patients with no other causes of liver disease." Their conclusion is: "Further research on liver damage due to sleep apnea is needed to assess the prevalence of OSA in patients with Nash [NASH, or fatty liver inflammation], and to assess whether there is a treatment of OSA may improve liver injury."
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